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For decades, lithium has been one of the most trusted treatments for bipolar disorder. But long-term use can have side effects, including kidney failure and a condition called nephrogenic diabetes insipidus, which interferes with the body’s ability to manage fluids.
Anyone taking lithium should be closely monitored with regular blood work and kidney checkups. This is not a medication to manage without a strong partnership between psychiatrist and nephrologist.
6. Diuretics — The “Water Pills”
But when used too aggressively or without monitoring, diuretics can dehydrate the body, upset electrolyte balance, and increase stress on the kidneys.
Important reminder: Never adjust the dose of a diuretic on your own. Even small changes can affect kidney function.
7. Blood Pressure Medications
Here’s where it gets tricky. Some renin-angiotensin system (RAS) inhibitors, a class of blood pressure medications, may affect kidney function over time.
But — and this is key — they are also essential for protecting the heart and controlling high blood pressure, which is one of the leading causes of kidney failure.
That means these medications should never be stopped suddenly. If you’re concerned, talk to your doctor. In many cases, the benefits outweigh the risks, but dosage and monitoring are critical.
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